Eating too much dietary fat at one time releases toxins that not only promote body fat accumulation but may also increase your risk for colon cancer, according to new research from the University of Texas Southwestern Medical Center in Dallas.

Their findings, published this year in the journal Science, reveals the body’s natural mechanisms aren’t built to handle lithocholic acid, a toxic byproduct of dietary fat, in the volume generated by high-fat diets.

“Lithocholic acid is highly toxic, and it builds up in a high-fat diet,” says lead researcher Dr. David Mangelsdorf, professor of pharmacology at UT Southwestern.

“We don’t know how it causes cancer; but it is known to cause cancer in mice, and people with colon cancer have high concentrations of it.”

Dr. Mangelsdorf says the body’s natural lithocholic acid-response mechanism simply wasn’t built to handle the amount of fat in the modern American diet.

What This Means to You: “Our bodies can handle slight changes in lithocholic acid that come from a normal diet, but not a high-fat diet,” says Dr. Mangelsdorf.

“The current American diet can provide more fat on a daily basis than a human being was ever meant to handle.

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