The state in which a place, person or civilized environment or one’s mental ability is put into a psychological status of distress, forsaken, mentally discomforted etc.
noun
1.
a state of complete emptiness or destruction or hopelessness.

“I suddenly felt desolate and and overwelmed with the feeling of loss, hopelessness, mournfulness, terror, unhappiness, sadness, & loneliness etc.”

Isaiah 13:9:

Behold, the day of the Lord comes, Cruel, with both wrath and fierce anger,

To lay the land desolate; And He will destroy its sinners from it.

synonyms:

barrenness, bleakness, starkness, bareness, dismalness, grimness, mournfulness
feeling or showing great unhappiness or loneliness.

The emotional state where person finds him/herself loosing interest, finding no purpose in the things that he/she trusted. –

To become useless, purposeless, up to no good, hopeless, mournful, puting some into the state of depression.

synonyms:

miserable, sad, unhappy, melancholy, gloomy, glum, despondent, comfortless, depressed, mournfulness, disconsolate, sorrowful;

The state of desolation has the ability to activate dreams of zombies, mad, violent people exercising their evil deeds against others.

Job 7:13-15

13 When I say, ‘My bed will comfort me, My couch will ease my complaint,’

14 Then You scare me with dreams And terrify me with visions,

15 So that my soul chooses strangling And death rather than my body.

“the droughts that desolated the dry plains”

synonyms:

devastate, ravage, ruin, make/leave desolate, leave in ruins, destroy, wreck, lay waste to, wreak havoc on; More
2.
make (someone) feel utterly wretched and unhappy.

“he was desolated by the deaths of his treasured friends”
synonyms: dishearten, dispirit, daunt, distress, depress, make sad/unhappy, sadden, cast down, deject, make miserable, make gloomy/despondent, weigh down, oppress;

: unpromising, unfavourable, disadvantageous, undecorated, uncomfortable, discouraging, disheartening, depressing, cheerless, joyless,
3.
great unhappiness or loneliness.